Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA

The human sliding clamp, Proliferating Cell Nuclear Antigen (hPCNA), interacts with over 200 proteins through a conserved binding motif, the PIP-box, to orchestrate DNA replication and repair. It is not clear how changes to the features of a PIP-box modulate protein binding and thus how they fine-tu...

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Detalles Bibliográficos
Autores principales: Horsfall, Aimee J., Vandborg, Beth A., Kowalczyk, Wioleta, Chav, Theresa, Scanlon, Denis B., Abell, Andrew D., Bruning, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191301/
https://www.ncbi.nlm.nih.gov/pubmed/33984330
http://dx.doi.org/10.1016/j.jbc.2021.100773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191301/
https://www.ncbi.nlm.nih.gov/pubmed/33984330
http://dx.doi.org/10.1016/j.jbc.2021.100773

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