Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation

Cathepsin H (CTSH) is a type 1 diabetes (T1D) risk gene; large-scale genetic and epidemiological studies found that T1D genetic risk correlates with high CTSH expression, rapid decline of beta-cell function, and early onset T1D. Counterintuitively, transcriptional downregulation of CTSH by proinflam...

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Detalles Bibliográficos
Autores principales: Ye, Jody, Stefan-Lifshitz, Mihaela, Tomer, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191311/
https://www.ncbi.nlm.nih.gov/pubmed/33992646
http://dx.doi.org/10.1016/j.jbc.2021.100774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191311/
https://www.ncbi.nlm.nih.gov/pubmed/33992646
http://dx.doi.org/10.1016/j.jbc.2021.100774

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