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Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation

Cathepsin H (CTSH) is a type 1 diabetes (T1D) risk gene; large-scale genetic and epidemiological studies found that T1D genetic risk correlates with high CTSH expression, rapid decline of beta-cell function, and early onset T1D. Counterintuitively, transcriptional downregulation of CTSH by proinflam...

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Detalles Bibliográficos
Autores principales:	Ye, Jody, Stefan-Lifshitz, Mihaela, Tomer, Yaron
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191311/ https://www.ncbi.nlm.nih.gov/pubmed/33992646 http://dx.doi.org/10.1016/j.jbc.2021.100774

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