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Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport
K(+)–Cl(−) cotransporters (KCCs) play important roles in physiological processes such as inhibitory neurotransmission and cell-volume regulation. KCCs exhibit significant variations in K(+) affinities, yet recent atomic structures demonstrated that K(+)- and Cl(−)-binding sites are highly conserved,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191313/ https://www.ncbi.nlm.nih.gov/pubmed/34019872 http://dx.doi.org/10.1016/j.jbc.2021.100793 |