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Driving forces in amyloidosis: How does a light chain make a heavy heart?
Light-chain amyloidosis (AL) is a fatal disorder wherein the immunoglobulin light chain misfolds and aggregates, leading to amyloid plaques in various organs. Patient-specific mutations in the light chain variable domain (V(L)) are tightly linked to amyloidosis, but how these mutations drive AL is u...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191319/ https://www.ncbi.nlm.nih.gov/pubmed/34019874 http://dx.doi.org/10.1016/j.jbc.2021.100785 |