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The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II

The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex mediator, which regulates gene transcription by RNA polymerase II. The CKM has both negative and positive functions in gene transcription that remain poorly understood at the mechanistic level. In order to reconstitute the...

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Detalles Bibliográficos
Autores principales: Osman, Sara, Mohammad, Eusra, Lidschreiber, Michael, Stuetzer, Alexandra, Bazsó, Fanni Laura, Maier, Kerstin C., Urlaub, Henning, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191332/
https://www.ncbi.nlm.nih.gov/pubmed/33933450
http://dx.doi.org/10.1016/j.jbc.2021.100734