Post-translational modification of RNA m(6)A demethylase ALKBH5 regulates ROS-induced DNA damage response

Faithful genome integrity maintenance plays an essential role in cell survival. Here, we identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA damage and apoptosis during reactive oxygen species (ROS)-induced stress. We find that ROS significantly induces global mRNA N(...

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Detalles Bibliográficos
Autores principales: Yu, Fang, Wei, Jiangbo, Cui, Xiaolong, Yu, Chunjie, Ni, Wei, Bungert, Jörg, Wu, Lizi, He, Chuan, Qian, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191756/
https://www.ncbi.nlm.nih.gov/pubmed/34048572
http://dx.doi.org/10.1093/nar/gkab415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191756/
https://www.ncbi.nlm.nih.gov/pubmed/34048572
http://dx.doi.org/10.1093/nar/gkab415

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