Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP

Replication of the ∼30 kb-long coronavirus genome is mediated by a complex of non-structural proteins (NSP), in which NSP7 and NSP8 play a critical role in regulating the RNA-dependent RNA polymerase (RdRP) activity of NSP12. The assembly of NSP7, NSP8 and NSP12 proteins is highly dynamic in solutio...

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Detalles Bibliográficos
Autores principales: Biswal, Mahamaya, Diggs, Stephen, Xu, Duo, Khudaverdyan, Nelli, Lu, Jiuwei, Fang, Jian, Blaha, Gregor, Hai, Rong, Song, Jikui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191759/
https://www.ncbi.nlm.nih.gov/pubmed/33999154
http://dx.doi.org/10.1093/nar/gkab370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191759/
https://www.ncbi.nlm.nih.gov/pubmed/33999154
http://dx.doi.org/10.1093/nar/gkab370

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