Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent inhibitor of aminoacylation of tRNA(Pro) with broad biomedical applications. Here, we show that in addition to translationa...

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Detalles Bibliográficos
Autores principales: Misra, Jagannath, Holmes, Michael J, T. Mirek, Emily, Langevin, Michael, Kim, Hyeong-Geug, Carlson, Kenneth R, Watford, Malcolm, Dong, X Charlie, Anthony, Tracy G, Wek, Ronald C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191763/
https://www.ncbi.nlm.nih.gov/pubmed/34023907
http://dx.doi.org/10.1093/nar/gkab362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191763/
https://www.ncbi.nlm.nih.gov/pubmed/34023907
http://dx.doi.org/10.1093/nar/gkab362

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