Cargando…

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent inhibitor of aminoacylation of tRNA(Pro) with broad biomedical applications. Here, we show that in addition to translationa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Misra, Jagannath, Holmes, Michael J, T. Mirek, Emily, Langevin, Michael, Kim, Hyeong-Geug, Carlson, Kenneth R, Watford, Malcolm, Dong, X Charlie, Anthony, Tracy G, Wek, Ronald C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191763/ https://www.ncbi.nlm.nih.gov/pubmed/34023907 http://dx.doi.org/10.1093/nar/gkab362

Ejemplares similares

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
por: Cordova, Ricardo A, et al.
Publicado: (2022)

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
por: Zaborske, John M, et al.
Publicado: (2010)

The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids
por: Miles, Rebecca R., et al.
Publicado: (2021)

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
por: Augusto, Leonardo, et al.
Publicado: (2019)

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
por: Ye, Jiangbin, et al.
Publicado: (2015)

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
por: Averous, Julien, et al.
Publicado: (2016)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
por: Gandin, Valentina, et al.
Publicado: (2016)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Activation of Gcn2 by small molecules designed to be inhibitors
por: Carlson, Kenneth R., et al.
Publicado: (2023)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Translational repression protects human keratinocytes from UVB-induced apoptosis through a discordant eIF2 kinase stress response
por: Collier, Ann E., et al.
Publicado: (2015)

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
por: Klann, Kevin, et al.
Publicado: (2020)

Effects of mTORC1 inhibition on proteasome activity and levels
por: Park, Seo Hyeong, et al.
Publicado: (2022)

mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2018)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Receptor-Recognized α(2)-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells
por: Misra, Uma K., et al.
Publicado: (2012)

Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis
por: Sparta, Breanne, et al.
Publicado: (2023)

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)
por: Rios-Fuller, Tiffany J., et al.
Publicado: (2020)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling
por: Fulton, Tahlia L., et al.
Publicado: (2022)

mTORC1 regulates nutrient access in Ras-mediated tumors
por: Cheong, Heesun
Publicado: (2016)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
por: Wang, Fangjie, et al.
Publicado: (2018)

Localization of mTORC2 activity inside cells
por: Ebner, Michael, et al.
Publicado: (2017)

Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish
por: Zhou, Wen-Hao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v7v7ip1uek3h5gifu801koj1q2