Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes

DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription. The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers. However, the most studied MycG4 sequence bears a mutated 3′-residue crucial for ligand recognition. Here, we report a new drug-like small mole...

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Detalles Bibliográficos
Autores principales: Dickerhoff, Jonathan, Dai, Jixun, Yang, Danzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191789/
https://www.ncbi.nlm.nih.gov/pubmed/33978746
http://dx.doi.org/10.1093/nar/gkab330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191789/
https://www.ncbi.nlm.nih.gov/pubmed/33978746
http://dx.doi.org/10.1093/nar/gkab330

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