Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance

Cancer-causing missense mutations in the 3418 amino acid BRCA2 breast and ovarian cancer suppressor protein frequently affect a short (∼340 residue) segment in its carboxyl-terminal domain (DBD). Here, we identify a shared molecular mechanism underlying their pathogenicity. Pathogenic BRCA2 missense...

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Detalles Bibliográficos
Autores principales: Lee, Miyoung, Shorthouse, David, Mahen, Robert, Hall, Benjamin A, Venkitaraman, Ashok R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191791/
https://www.ncbi.nlm.nih.gov/pubmed/33978741
http://dx.doi.org/10.1093/nar/gkab308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191791/
https://www.ncbi.nlm.nih.gov/pubmed/33978741
http://dx.doi.org/10.1093/nar/gkab308

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