Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice

Modification of the Per2 clock gene in mPer2(Luc) reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced phase resetting to light pulses, a...

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Detalles Bibliográficos
Autores principales: Ralph, Martin R., Shi, Shu-qun, Johnson, Carl H., Houdek, Pavel, Shrestha, Tenjin C., Crosby, Priya, O’Neill, John S., Sládek, Martin, Stinchcombe, Adam R., Sumová, Alena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191895/
https://www.ncbi.nlm.nih.gov/pubmed/34048425
http://dx.doi.org/10.1371/journal.pcbi.1008987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191895/
https://www.ncbi.nlm.nih.gov/pubmed/34048425
http://dx.doi.org/10.1371/journal.pcbi.1008987

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