P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity

The final stage of Ebola virus (EBOV) replication is budding from host cells, where the matrix protein VP40 is essential for driving this process. Many post-translational modifications such as ubiquitination are involved in VP40 egress, but acetylation has not been studied yet. Here, we characterize...

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Detalles Bibliográficos
Autores principales: Zhang, Linliang, Zhou, Shixiong, Chen, Majuan, Yan, Jie, Yang, Yi, Wu, Linjuan, Jin, Dongning, Yin, Lei, Chen, Mingzhou, Qin, Yali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191996/
https://www.ncbi.nlm.nih.gov/pubmed/34111220
http://dx.doi.org/10.1371/journal.ppat.1009616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191996/
https://www.ncbi.nlm.nih.gov/pubmed/34111220
http://dx.doi.org/10.1371/journal.ppat.1009616

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