Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones

8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-d-ribose-2′-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen Mycobacter...

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Detalles Bibliográficos
Autores principales: Madikizela, Balungile, Eckhardt, Tamira, Goddard, Richard, Richter, Adrian, Lins, Anika, Lehmann, Christoph, Imming, Peter, Seidel, Rüdiger W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192043/
https://www.ncbi.nlm.nih.gov/pubmed/34131377
http://dx.doi.org/10.1007/s00044-021-02735-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192043/
https://www.ncbi.nlm.nih.gov/pubmed/34131377
http://dx.doi.org/10.1007/s00044-021-02735-4

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