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Myocardial salvage by succinate dehydrogenase inhibition in ischemia–reperfusion injury depends on diabetes stage in rats

Inhibition of succinate dehydrogenase (SDH) by Dimethyl Malonate (DiMal) reduces cardiac ischemia–reperfusion (IR) injury. We investigated the cardioprotective effect of DiMal in a rat model during advancing type 2 diabetes. Zucker Diabetic Fatty rats and lean controls were investigated correspondin...

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Detalles Bibliográficos
Autores principales: Tonnesen, Pernille Tilma, Hjortbak, Marie Vognstoft, Lassen, Thomas Ravn, Seefeldt, Jacob Marthinsen, Bøtker, Hans Erik, Jespersen, Nichlas Riise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192402/
https://www.ncbi.nlm.nih.gov/pubmed/33666828
http://dx.doi.org/10.1007/s11010-021-04108-2