Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise to a poorly characterized spectrum of chromosome structural abnormalities. Here, using...

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Detalles Bibliográficos
Autores principales: Leibowitz, Mitchell L., Papathanasiou, Stamatis, Doerfler, Phillip A., Blaine, Logan J., Sun, Lili, Yao, Yu, Zhang, Cheng-Zhong, Weiss, Mitchell J., Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192433/
https://www.ncbi.nlm.nih.gov/pubmed/33846636
http://dx.doi.org/10.1038/s41588-021-00838-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192433/
https://www.ncbi.nlm.nih.gov/pubmed/33846636
http://dx.doi.org/10.1038/s41588-021-00838-7

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