ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues

Mysteriously neurons maintain ATP concentrations of ~3 mM but whether ATP modulates TDP-43 LLPS remains completely unexplored. Here we characterized the effect of ATP on LLPS of TDP-43 PLD and seven mutants by DIC and NMR. The results revealed: 1) ATP induces and subsequently dissolves LLPS of TDP-4...

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Detalles Bibliográficos
Autores principales: Dang, Mei, Lim, Liangzhong, Kang, Jian, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192790/
https://www.ncbi.nlm.nih.gov/pubmed/34112944
http://dx.doi.org/10.1038/s42003-021-02247-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192790/
https://www.ncbi.nlm.nih.gov/pubmed/34112944
http://dx.doi.org/10.1038/s42003-021-02247-2

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