Notch inhibitors induce diarrhea, hypercrinia and secretory cell metaplasia in the human colon

In humans, inhibition of Notch oncogenic signaling leads to tumor regression. Preclinical studies indicate that Notch signaling contributes to the maintenance of intestinal homeostasis. Here, we sought to describe the intestinal effects of a first-in-human Notch inhibitor in an indication of refract...

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Detalles Bibliográficos
Autores principales: Collins, Michael, Michot, Jean-Marie, Bellanger, Christophe, Mussini, Charlotte, Benhadji, Karim, Massard, Christophe, Carbonnel, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192874/
https://www.ncbi.nlm.nih.gov/pubmed/34121974
http://dx.doi.org/10.17179/excli2021-3572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192874/
https://www.ncbi.nlm.nih.gov/pubmed/34121974
http://dx.doi.org/10.17179/excli2021-3572

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