Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologies

Phosphodiesterase (PDE) inhibitors, such as pentoxifylline (PTX), are used as pharmacological agents to enhance sperm motility in assisted reproductive technology (ART), mainly to aid the selection of viable sperm in asthenozoospermic ejaculates and testicular spermatozoa, prior to intracytoplasmic...

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Detalles Bibliográficos
Autores principales: Satish, Mutyala, Kumari, Sandhya, Deeksha, Waghela, Abhishek, Suman, Nitin, Kulhar, Adiga, Satish Kumar, Hegde, Padmaraj, Dasappa, Jagadeesh Prasad, Kalthur, Guruprasad, Rajakumara, Eerappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192908/
https://www.ncbi.nlm.nih.gov/pubmed/34112881
http://dx.doi.org/10.1038/s41598-021-91636-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192908/
https://www.ncbi.nlm.nih.gov/pubmed/34112881
http://dx.doi.org/10.1038/s41598-021-91636-y

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