KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

Metabolic reprogramming in cancer cells can create metabolic liabilities. KEAP1-mutant lung cancer is refractory to most current therapies. Here we show that KEAP1 deficiency promotes glucose dependency in lung cancer cells, and KEAP1-mutant/deficient lung cancer cells are more vulnerable to glucose...

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Detalles Bibliográficos
Autores principales: Koppula, Pranavi, Olszewski, Kellen, Zhang, Yilei, Kondiparthi, Lavanya, Liu, Xiaoguang, Lei, Guang, Das, Molina, Fang, Bingliang, Poyurovsky, Masha V., Gan, Boyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193145/
https://www.ncbi.nlm.nih.gov/pubmed/34151236
http://dx.doi.org/10.1016/j.isci.2021.102649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193145/
https://www.ncbi.nlm.nih.gov/pubmed/34151236
http://dx.doi.org/10.1016/j.isci.2021.102649

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