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Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist
We report the discovery of strong HNF4α agonists and their use to uncover a previously unknown pathway by which HNF4α controls the level of fat storage in the liver. This involves the induction of lipophagy by dihydroceramides, the synthesis and secretion of which is controlled by genes induced by H...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193211/ https://www.ncbi.nlm.nih.gov/pubmed/34117215 http://dx.doi.org/10.1038/s41419-021-03862-x |