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Heterologous expression of MlcE in Saccharomyces cerevisiae provides resistance to natural and semi-synthetic statins
Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the key enzyme in cholesterol biosynthesis. Their extensive use in treatment and prevention of cardiovascular diseases placed statins among the best selling drugs. Construction of Saccharomyces cerevisiae cell factory for the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193252/ https://www.ncbi.nlm.nih.gov/pubmed/34150514 http://dx.doi.org/10.1016/j.meteno.2015.09.003 |