Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors

In mammalian cells, the L-type amino acid transporters (LATs) LAT1 (SLC7A5) and LAT2 (SLC7A8) form heterodimeric amino acid transporters (HATs) with the ancillary protein 4F2hc and are involved in the cellular uptake of specific amino acids. The HAT 4F2hc-LAT1 is found upregulated in various cancer...

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Detalles Bibliográficos
Autores principales: Kantipudi, Satish, Fotiadis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193492/
https://www.ncbi.nlm.nih.gov/pubmed/34124158
http://dx.doi.org/10.3389/fmolb.2021.676854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193492/
https://www.ncbi.nlm.nih.gov/pubmed/34124158
http://dx.doi.org/10.3389/fmolb.2021.676854

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