Selective Wnt/β-Catenin Pathway Activation Concomitant With Sustained Overexpression of miR-21 is Responsible for Aristolochic Acid-Induced AKI-to-CKD Transition

Acute kidney injury (AKI) is increasingly recognized as a cumulative risk factor for chronic kidney disease (CKD) progression. However, the underlying mechanisms remain unclear. Using an aristolochic acid (AA)-induced mouse model of AKI-to-CKD transition, we found that the development of tubulointer...

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Detalles Bibliográficos
Autores principales: Kuang, Qing, Wu, Sheng, Xue, Ning, Wang, Xiaoyan, Ding, Xiaoqianq, Fang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193720/
https://www.ncbi.nlm.nih.gov/pubmed/34122087
http://dx.doi.org/10.3389/fphar.2021.667282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193720/
https://www.ncbi.nlm.nih.gov/pubmed/34122087
http://dx.doi.org/10.3389/fphar.2021.667282

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