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Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies
Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193947/ https://www.ncbi.nlm.nih.gov/pubmed/34123850 http://dx.doi.org/10.3389/fonc.2021.680834 |
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author | Zhao, Yuming Zhang, Dengyang Guo, Yao Lu, Bo Zhao, Zhizhuang Joe Xu, Xiaojun Chen, Yun |
author_facet | Zhao, Yuming Zhang, Dengyang Guo, Yao Lu, Bo Zhao, Zhizhuang Joe Xu, Xiaojun Chen, Yun |
author_sort | Zhao, Yuming |
collection | PubMed |
description | Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. However, small molecule inhibitors targeting ROR1 are underappreciated because of the initial characterization of ROR1 as a peusdokinase. The function of ROR1 as a tyrosine kinase remains poorly understood, although accumulating evidence have demonstrated its intrinsic tyrosine kinase activity. In this review, we analyzed the structural and functional features of ROR1 and discussed therapeutic strategies targeting this kinase. |
format | Online Article Text |
id | pubmed-8193947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81939472021-06-12 Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies Zhao, Yuming Zhang, Dengyang Guo, Yao Lu, Bo Zhao, Zhizhuang Joe Xu, Xiaojun Chen, Yun Front Oncol Oncology Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. However, small molecule inhibitors targeting ROR1 are underappreciated because of the initial characterization of ROR1 as a peusdokinase. The function of ROR1 as a tyrosine kinase remains poorly understood, although accumulating evidence have demonstrated its intrinsic tyrosine kinase activity. In this review, we analyzed the structural and functional features of ROR1 and discussed therapeutic strategies targeting this kinase. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8193947/ /pubmed/34123850 http://dx.doi.org/10.3389/fonc.2021.680834 Text en Copyright © 2021 Zhao, Zhang, Guo, Lu, Zhao, Xu and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhao, Yuming Zhang, Dengyang Guo, Yao Lu, Bo Zhao, Zhizhuang Joe Xu, Xiaojun Chen, Yun Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies |
title | Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies |
title_full | Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies |
title_fullStr | Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies |
title_full_unstemmed | Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies |
title_short | Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies |
title_sort | tyrosine kinase ror1 as a target for anti-cancer therapies |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193947/ https://www.ncbi.nlm.nih.gov/pubmed/34123850 http://dx.doi.org/10.3389/fonc.2021.680834 |
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