An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability

Tumor heterogeneity is a primary cause of treatment failure and acquired resistance in cancer patients. Even in cancers driven by a single mutated oncogene, variability in response to targeted therapies is well known. The existence of additional genomic alterations among tumor cells can only partial...

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Detalles Bibliográficos
Autores principales: Hayford, Corey E., Tyson, Darren R., Robbins, C. Jack, Frick, Peter L., Quaranta, Vito, Harris, Leonard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195356/
https://www.ncbi.nlm.nih.gov/pubmed/34061819
http://dx.doi.org/10.1371/journal.pbio.3000797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195356/
https://www.ncbi.nlm.nih.gov/pubmed/34061819
http://dx.doi.org/10.1371/journal.pbio.3000797

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