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An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability
Tumor heterogeneity is a primary cause of treatment failure and acquired resistance in cancer patients. Even in cancers driven by a single mutated oncogene, variability in response to targeted therapies is well known. The existence of additional genomic alterations among tumor cells can only partial...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195356/ https://www.ncbi.nlm.nih.gov/pubmed/34061819 http://dx.doi.org/10.1371/journal.pbio.3000797 |