Increased expression of adenosine 2A receptors in metastatic renal cell carcinoma is associated with poorer response to anti-vascular endothelial growth factor agents and anti-PD-1/Anti-CTLA4 antibodies and shorter survival

BACKGROUND: Adenosine and its adenosine 2A receptors (A2AR) mediate the immunosuppressive mechanism by which tumors escape immunosurveillance and impede anti-tumor immunity within the tumor microenvironment. However, we do not know whether the adenosine pathway (CD39/CD73/A2AR) plays a role in renal...

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Detalles Bibliográficos
Autores principales: Kamai, Takao, Kijima, Toshiki, Tsuzuki, Toyonori, Nukui, Akinori, Abe, Hideyuki, Arai, Kyoko, Yoshida, Ken-Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195893/
https://www.ncbi.nlm.nih.gov/pubmed/33416945
http://dx.doi.org/10.1007/s00262-020-02843-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195893/
https://www.ncbi.nlm.nih.gov/pubmed/33416945
http://dx.doi.org/10.1007/s00262-020-02843-x

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