Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS

Transactive response DNA-binding protein 43 kDa (TDP-43) encoded by the TARDBP gene is an evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that regulates multiple steps of RNA metabolism, and its cytoplasmic aggregation characterizes degenerating motor neurons in amyotrophic...

Descripción completa

Detalles Bibliográficos
Autores principales: Asakawa, Kazuhide, Handa, Hiroshi, Kawakami, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195926/
https://www.ncbi.nlm.nih.gov/pubmed/33709256
http://dx.doi.org/10.1007/s00018-021-03792-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195926/
https://www.ncbi.nlm.nih.gov/pubmed/33709256
http://dx.doi.org/10.1007/s00018-021-03792-z

Ejemplares similares