E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6),...

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Detalles Bibliográficos
Autores principales: Dahlet, Thomas, Truss, Matthias, Frede, Ute, Al Adhami, Hala, Bardet, Anaïs F., Dumas, Michael, Vallet, Judith, Chicher, Johana, Hammann, Philippe, Kottnik, Sarah, Hansen, Peter, Luz, Uschi, Alvarez, Gonzalo, Auclair, Ghislain, Hecht, Jochen, Robinson, Peter N., Hagemeier, Christian, Weber, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195999/
https://www.ncbi.nlm.nih.gov/pubmed/34117224
http://dx.doi.org/10.1038/s41467-021-23596-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195999/
https://www.ncbi.nlm.nih.gov/pubmed/34117224
http://dx.doi.org/10.1038/s41467-021-23596-w

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