The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

Arpp19 is a potent PP2A-B55 inhibitor that regulates this phosphatase to ensure the stable phosphorylation of mitotic/meiotic substrates. At G2-M, Arpp19 is phosphorylated by the Greatwall kinase on S67. This phosphorylated Arpp19 form displays a high affinity to PP2A-B55 and a slow dephosphorylatio...

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Detalles Bibliográficos
Autores principales: Labbé, Jean Claude, Vigneron, Suzanne, Méchali, Francisca, Robert, Perle, Roque, Sylvain, Genoud, Cindy, Goguet-Rubio, Perrine, Barthe, Phillipe, Labesse, Gilles, Cohen-Gonsaud, Martin, Castro, Anna, Lorca, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196004/
https://www.ncbi.nlm.nih.gov/pubmed/34117214
http://dx.doi.org/10.1038/s41467-021-23657-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196004/
https://www.ncbi.nlm.nih.gov/pubmed/34117214
http://dx.doi.org/10.1038/s41467-021-23657-0

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