AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections

Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it is not known if this evolutionar...

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Detalles Bibliográficos
Autores principales: Bone, Nathaniel B., Becker, Eugene J., Husain, Maroof, Jiang, Shaoning, Zmijewska, Anna A., Park, Dae-Won, Chacko, Balu, Darley-Usmar, Victor, Grégoire, Murielle, Tadie, Jean-Marc, Thannickal, Victor J., Zmijewski, Jaroslaw W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196038/
https://www.ncbi.nlm.nih.gov/pubmed/34117280
http://dx.doi.org/10.1038/s41598-021-90573-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196038/
https://www.ncbi.nlm.nih.gov/pubmed/34117280
http://dx.doi.org/10.1038/s41598-021-90573-0

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