Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the pathogenesis of myeloproliferative neoplasms (MPNs) in an endogenous context, we modeled the CALRdel52 and CAL...

Descripción completa

Detalles Bibliográficos
Autores principales: Secardin, Lise, Gomez Limia, Cintia, da Silva-Benedito, Suzana, Lordier, Larissa, El-Khoury, Mira, Marty, Caroline, Ianotto, Jean-Christophe, Raslova, Hana, Constantinescu, Stefan N., Bonamino, Martín Hernán, Vainchenker, William, Monte-Mor, Barbara, Di Stefano, Antonio, Plo, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196125/
https://www.ncbi.nlm.nih.gov/pubmed/34131633
http://dx.doi.org/10.1097/HS9.0000000000000593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196125/
https://www.ncbi.nlm.nih.gov/pubmed/34131633
http://dx.doi.org/10.1097/HS9.0000000000000593

Ejemplares similares