Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains

Cyclic AMP (cAMP)-dependent signaling is highly implicated in the pathophysiology of alcohol use disorder (AUD), with evidence supporting the efficacy of inhibiting the cAMP hydrolyzing enzyme phosphodiesterase 4 (PDE4) as a therapeutic strategy for drinking reduction. Off-target emetic effects asso...

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Detalles Bibliográficos
Autores principales: Jimenez Chavez, C. Leonardo, Bryant, Camron D., Munn-Chernoff, Melissa A., Szumlinski, Karen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196757/
https://www.ncbi.nlm.nih.gov/pubmed/34064099
http://dx.doi.org/10.3390/ijms22115443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196757/
https://www.ncbi.nlm.nih.gov/pubmed/34064099
http://dx.doi.org/10.3390/ijms22115443

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