Structure, Dynamics, and Ligand Recognition of Human-Specific CHRFAM7A (Dupα7) Nicotinic Receptor Linked to Neuropsychiatric Disorders

Cholinergic α7 nicotinic receptors encoded by the CHRNA7 gene are ligand-gated ion channels directly related to memory and immunomodulation. Exons 5–7 in CHRNA7 can be duplicated and fused to exons A-E of FAR7a, resulting in a hybrid gene known as CHRFAM7A, unique to humans. Its product, denoted her...

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Detalles Bibliográficos
Autores principales: Liu, Danlin, de Souza, João V., Ahmad, Ayaz, Bronowska, Agnieszka K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196834/
https://www.ncbi.nlm.nih.gov/pubmed/34067314
http://dx.doi.org/10.3390/ijms22115466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196834/
https://www.ncbi.nlm.nih.gov/pubmed/34067314
http://dx.doi.org/10.3390/ijms22115466

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