Synthesis and Characterization of Some New Quinoxalin-2(1H)one and 2-Methyl-3H-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SAR, Molecular Docking, and ADMET Analyses

The pathogenesis of colorectal cancer is a multifactorial process. Dysbiosis and the overexpression of COX-2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and induction of the Warburg effect, respectively. Herein...

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Detalles Bibliográficos
Autores principales: El-Sayed, Nahed N. E., Al-Otaibi, Taghreed M., Alonazi, Mona, Masand, Vijay H., Barakat, Assem, Almarhoon, Zainab M., Ben Bacha, Abir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197120/
https://www.ncbi.nlm.nih.gov/pubmed/34071141
http://dx.doi.org/10.3390/molecules26113121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197120/
https://www.ncbi.nlm.nih.gov/pubmed/34071141
http://dx.doi.org/10.3390/molecules26113121

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