Cargando…
Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer’s Disease (Mouse Model) through Autophagy Induced by Activating Axl
Alzheimer’s disease (AD) is thought to be caused by amyloid-β (Aβ) accumulation in the central nervous system due to deficient clearance. The aim of the present study was to investigate the effect of ganoderic acid A (GAA) on Aβ clearance in microglia and its anti-AD activity. Aβ degradation in BV2...
Autores principales: | Qi, Li-Feng-Rong, Liu, Shuai, Liu, Yu-Ci, Li, Ping, Xu, Xiaojun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197357/ https://www.ncbi.nlm.nih.gov/pubmed/34074054 http://dx.doi.org/10.3390/ijms22115559 |
Ejemplares similares
-
Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway
por: Zhang, Mu, et al.
Publicado: (2018) -
Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance
por: Pan, Rui-Yuan, et al.
Publicado: (2019) -
Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease
por: Zhao, Yue, et al.
Publicado: (2020) -
Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease
por: Wang, Jiangong, et al.
Publicado: (2021) -
Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases
por: Wu, Jiumn-Yih, et al.
Publicado: (2021)