Cargando…

Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease

Biomolecular condensation via liquid–liquid phase separation (LLPS) of intrinsically disordered proteins/regions (IDPs/IDRs), with and without nucleic acids, has drawn widespread interest due to the rapidly unfolding role of phase‐separated condensates in a diverse range of cellular functions and hu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rai, Sandeep K., Savastano, Adriana, Singh, Priyanka, Mukhopadhyay, Samrat, Zweckstetter, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197432/ https://www.ncbi.nlm.nih.gov/pubmed/33930220 http://dx.doi.org/10.1002/pro.4093

Ejemplares similares

Interplay between tau and α‐synuclein liquid–liquid phase separation
por: Siegert, Anna, et al.
Publicado: (2021)

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
por: Ambadipudi, Susmitha, et al.
Publicado: (2017)

Single-droplet surface-enhanced Raman scattering decodes the molecular determinants of liquid-liquid phase separation
por: Avni, Anamika, et al.
Publicado: (2022)

Peptidyl Prolyl Isomerase A Modulates the Liquid–Liquid Phase Separation of Proline-Rich IDPs
por: Babu, Maria, et al.
Publicado: (2022)

Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates
por: Rai, Sandeep K., et al.
Publicado: (2023)

Tau protein liquid–liquid phase separation can initiate tau aggregation
por: Wegmann, Susanne, et al.
Publicado: (2018)

EFhd2 Affects Tau Liquid–Liquid Phase Separation
por: Vega, Irving E., et al.
Publicado: (2019)

Liquid-liquid phase separation induces pathogenic tau conformations in vitro
por: Kanaan, Nicholas M., et al.
Publicado: (2020)

Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions
por: Boyko, Solomiia, et al.
Publicado: (2019)

The proline-rich domain promotes Tau liquid–liquid phase separation in cells
por: Zhang, Xuemei, et al.
Publicado: (2020)

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity
por: Dai, Bin, et al.
Publicado: (2021)

Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases
por: Carey, Jenny L., et al.
Publicado: (2022)

Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein
por: Boyko, Solomiia, et al.
Publicado: (2023)

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

Liquid–Liquid Phase Separation in Cardiovascular Diseases
por: Mo, Yuanxi, et al.
Publicado: (2022)

Liquid–liquid phase separation in autophagy
por: Noda, Nobuo N., et al.
Publicado: (2020)

RNA and liquid-liquid phase separation
por: Guo, Qi, et al.
Publicado: (2021)

Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model
por: Wu, Chengchen, et al.
Publicado: (2021)

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope
por: Kang, Sang-Gyun, et al.
Publicado: (2021)

Dehydration entropy drives liquid-liquid phase separation by molecular crowding
por: Park, Sohee, et al.
Publicado: (2020)

Liquid–liquid phase separation in human health and diseases
por: Wang, Bin, et al.
Publicado: (2021)

Liquid–Liquid Phase Separation in Crowded Environments
por: André, Alain A. M., et al.
Publicado: (2020)

Targeting viral liquid–liquid phase separation
por: York, Ashley
Publicado: (2021)

Liquid–liquid phase separation in tumor biology
por: Tong, Xuhui, et al.
Publicado: (2022)

Open questions on liquid–liquid phase separation
por: Spruijt, Evan
Publicado: (2023)

Biomolecular Liquid–Liquid Phase Separation for Biotechnology
por: Shil, Sumit, et al.
Publicado: (2023)

Fabrication of microporous polyaryl nanofilm at the liquid-liquid interface for selective molecular separation
por: Dobariya, Priyanka, et al.
Publicado: (2023)

Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils
por: Savastano, Adriana, et al.
Publicado: (2020)

Dynamics of liquid-liquid phase separation of wheat gliadins
por: Boire, Adeline, et al.
Publicado: (2018)

Protein Databases Related to Liquid–Liquid Phase Separation
por: Li, Qian, et al.
Publicado: (2020)

Evidence for and against Liquid-Liquid Phase Separation in the Nucleus
por: A, Peng, et al.
Publicado: (2019)

Elastic ripening and inhibition of liquid-liquid phase separation
por: Rosowski, Kathryn A., et al.
Publicado: (2020)

Targeting liquid-liquid phase separation in pancreatic cancer
por: Ming, Yue, et al.
Publicado: (2019)

Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization
por: Qin, Da, et al.
Publicado: (2022)

The Role of Liquid–Liquid Phase Separation in Actin Polymerization
por: Povarova, Olga I., et al.
Publicado: (2023)

The effect of polymer length in liquid-liquid phase separation
por: Valdes-Garcia, Gilberto, et al.
Publicado: (2023)

Self-assembly coupled to liquid-liquid phase separation
por: Hagan, Michael F., et al.
Publicado: (2023)

Liquid–liquid phase separation within fibrillar networks
por: Liu, Jason X., et al.
Publicado: (2023)

Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
por: Wang, Yanwei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_o51qqjl9u0v4rpq9f10rdl35ki