Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited

Tuberous sclerosis, angiomyolipoma and lymphangioleiomyomatosis are a group of diseases characterized by mutation in tuberous sclerosis genes (TSC 1-2). TSC mutation leads to continuous activation of the mTOR pathway that requires adaptation to increased ATP requirement. With limited treatment optio...

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Detalles Bibliográficos
Autores principales: Abdelwahab, ElHusseiny M. M., Bovari-Biri, Judit, Smuk, Gabor, Fillinger, Janos, McPhail, Donald, Krymskaya, Vera P., Pongracz, Judit E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197715/
https://www.ncbi.nlm.nih.gov/pubmed/33860865
http://dx.doi.org/10.1007/s10495-021-01670-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197715/
https://www.ncbi.nlm.nih.gov/pubmed/33860865
http://dx.doi.org/10.1007/s10495-021-01670-4

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