Ca(2+) overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells

ABSTRACT: Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that δ-TT triggers apoptosis in human melanoma cells. Here, we investigated whether it might also activate...

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Detalles Bibliográficos
Autores principales: Raimondi, Michela, Fontana, Fabrizio, Marzagalli, Monica, Audano, Matteo, Beretta, Giangiacomo, Procacci, Patrizia, Sartori, Patrizia, Mitro, Nico, Limonta, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197726/
https://www.ncbi.nlm.nih.gov/pubmed/33811561
http://dx.doi.org/10.1007/s10495-021-01668-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197726/
https://www.ncbi.nlm.nih.gov/pubmed/33811561
http://dx.doi.org/10.1007/s10495-021-01668-y

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