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Ca(2+) overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells
ABSTRACT: Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that δ-TT triggers apoptosis in human melanoma cells. Here, we investigated whether it might also activate...
Autores principales: | Raimondi, Michela, Fontana, Fabrizio, Marzagalli, Monica, Audano, Matteo, Beretta, Giangiacomo, Procacci, Patrizia, Sartori, Patrizia, Mitro, Nico, Limonta, Patrizia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197726/ https://www.ncbi.nlm.nih.gov/pubmed/33811561 http://dx.doi.org/10.1007/s10495-021-01668-y |
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