Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specific Meprin β inhibitor. Our analysis of the crystal...

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Detalles Bibliográficos
Autores principales: Linnert, Miriam, Fritz, Claudia, Jäger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197800/
https://www.ncbi.nlm.nih.gov/pubmed/34073350
http://dx.doi.org/10.3390/ijms22115651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197800/
https://www.ncbi.nlm.nih.gov/pubmed/34073350
http://dx.doi.org/10.3390/ijms22115651

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