Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?

SIMPLE SUMMARY: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is aberrantly activated in many malignancies. Inhibition of this pathway via JAK inhibitors (JAKinibs) is therefore an attractive therapeutic strategy underlined by Ruxolitinib (JAK1/2 inhibitor) bei...

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Detalles Bibliográficos
Autores principales: Klein, Klara, Stoiber, Dagmar, Sexl, Veronika, Witalisz-Siepracka, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197909/
https://www.ncbi.nlm.nih.gov/pubmed/34073410
http://dx.doi.org/10.3390/cancers13112611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197909/
https://www.ncbi.nlm.nih.gov/pubmed/34073410
http://dx.doi.org/10.3390/cancers13112611

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