An Engineered sgsh Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA

Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumul...

Descripción completa

Detalles Bibliográficos
Autores principales: Douek, Alon M., Amiri Khabooshan, Mitra, Henry, Jason, Stamatis, Sebastian-Alexander, Kreuder, Florian, Ramm, Georg, Änkö, Minna-Liisa, Wlodkowic, Donald, Kaslin, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197930/
https://www.ncbi.nlm.nih.gov/pubmed/34073041
http://dx.doi.org/10.3390/ijms22115948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197930/
https://www.ncbi.nlm.nih.gov/pubmed/34073041
http://dx.doi.org/10.3390/ijms22115948

Ejemplares similares