Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioisomers for Antimalarial, Antiproliferative and Antimicrobial Activities

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher s...

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Detalles Bibliográficos
Autores principales: Håheim, Katja S., Lindbäck, Emil, Tan, Kah Ni, Albrigtsen, Marte, Urdal Helgeland, Ida T., Lauga, Clémence, Matringe, Théodora, Kennedy, Emily K., Andersen, Jeanette H., Avery, Vicky M., Sydnes, Magne O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198049/
https://www.ncbi.nlm.nih.gov/pubmed/34070798
http://dx.doi.org/10.3390/molecules26113268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198049/
https://www.ncbi.nlm.nih.gov/pubmed/34070798
http://dx.doi.org/10.3390/molecules26113268

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