Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking

Opioids are the most effective analgesics, with most clinically available opioids being agonists to the µ-opioid receptor (MOR). The MOR is also responsible for their unwanted effects, including reward and opioid misuse leading to the current public health crisis. The imperative need for safer, non-...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumitrascuta, Maria, Bermudez, Marcel, Trovato, Olga, De Neve, Jolien, Ballet, Steven, Wolber, Gerhard, Spetea, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198056/
https://www.ncbi.nlm.nih.gov/pubmed/34071603
http://dx.doi.org/10.3390/molecules26113267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198056/
https://www.ncbi.nlm.nih.gov/pubmed/34071603
http://dx.doi.org/10.3390/molecules26113267

Ejemplares similares