Intracellular Na(+) Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis

Background: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart’s primary pacemaker, are incompletely understood. Electrical and Ca(2+)-handling remodeling have been implicated in SAN dysfunction associated with heart failure, aging, and diabetes. Cardiomyocyte [Na(+)](i) i...

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Detalles Bibliográficos
Autores principales: Morotti, Stefano, Ni, Haibo, Peters, Colin H., Rickert, Christian, Asgari-Targhi, Ameneh, Sato, Daisuke, Glukhov, Alexey V., Proenza, Catherine, Grandi, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198068/
https://www.ncbi.nlm.nih.gov/pubmed/34073281
http://dx.doi.org/10.3390/ijms22115645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198068/
https://www.ncbi.nlm.nih.gov/pubmed/34073281
http://dx.doi.org/10.3390/ijms22115645

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