Cargando…

Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation

Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) contribute to the development of atherosclerosis and restenosis. Glycolysis and glutaminolysis are increased in rapidly proliferating VSMCs to support their increased energy requirements and biomass production. Thus, it is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Hyeon Young, Kim, Mi-Jin, Lee, Seunghyeong, Jin, Jonghwa, Lee, Sungwoo, Kim, Jung-Guk, Choi, Yeon-Kyung, Park, Keun-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198131/ https://www.ncbi.nlm.nih.gov/pubmed/34070527 http://dx.doi.org/10.3390/ijms22115602

Ejemplares similares

Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity
por: Lee, Seunghyeong, et al.
Publicado: (2022)

Cassiaside C Inhibits M1 Polarization of Macrophages by Downregulating Glycolysis
por: Kim, Ye Jin, et al.
Publicado: (2022)

Targeting glutamine metabolism as a therapeutic strategy for cancer
por: Jin, Jonghwa, et al.
Publicado: (2023)

Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2
por: Lee, Seunghyeong, et al.
Publicado: (2020)

DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation
por: Kumar, Sudeep, et al.
Publicado: (2022)

Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
por: Kim, Mi-Jin, et al.
Publicado: (2020)

Endothelial cell-derived SSAO can increase MLC(20) phosphorylation in VSMCs
por: Zhang, Yuxing, et al.
Publicado: (2021)

DN200434, an orally available inverse agonist of estrogen-related receptor γ, induces ferroptosis in sorafenib-resistant hepatocellular carcinoma
por: Kim, Dong-Ho, et al.
Publicado: (2022)

Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults
por: Jin, Jonghwa, et al.
Publicado: (2023)

Targeting Glutamine Metabolism for Cancer Treatment
por: Choi, Yeon-Kyung, et al.
Publicado: (2018)

Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
por: Seo, Jung Beom, et al.
Publicado: (2019)

DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation
por: Li, Mingyue, et al.
Publicado: (2021)

Year-Long Trend in Glycated Hemoglobin Levels in Patients with Type 2 Diabetes during the COVID-19 Pandemic
por: Jin, Jonghwa, et al.
Publicado: (2021)

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway
por: Kim, Yun H., et al.
Publicado: (2013)

Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation
por: Kong, Byung Soo, et al.
Publicado: (2016)

Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma
por: Noble, Richard A., et al.
Publicado: (2022)

Synthetic VSMCs induce BBB disruption mediated by MYPT1 in ischemic stroke
por: Meng, Hailan, et al.
Publicado: (2021)

HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs
por: Li, Lingfang, et al.
Publicado: (2016)

Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling
por: Xia, Yi, et al.
Publicado: (2023)

Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions
por: Soleimani, Ali Akbar, et al.
Publicado: (2022)

Role of Uric Acid in Vascular Remodeling: Cytoskeleton Changes and Migration in VSMCs
por: Russo, Elisa, et al.
Publicado: (2023)

Stretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes
por: Pappenhagen, Nathaniel, et al.
Publicado: (2022)

Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes
por: Zhao, Qingwen, et al.
Publicado: (2023)

Simultaneous Analysis of Fenthion and Its Five Metabolites in Produce Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
por: Lee, Jonghwa, et al.
Publicado: (2020)

Subcellular distribution of cGMP signalling proteins in VSMCs of IRAG KO mice
por: Hieke, Bernhard, et al.
Publicado: (2009)

Relaxation of Rat Aorta by Farrerol Correlates with Potency to Reduce Intracellular Calcium of VSMCs
por: Qin, Xiaojiang, et al.
Publicado: (2014)

Far-Infrared Irradiation Decreases Proliferation in Basal and PDGF-Stimulated VSMCs Through AMPK-Mediated Inhibition of mTOR/p70S6K Signaling Axis
por: Hwang, Yun-Jin, et al.
Publicado: (2023)

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
por: Gaude, Edoardo, et al.
Publicado: (2018)

The effects of a biodegradable Mg-based alloy on the function of VSMCs via immunoregulation of macrophages through Mg-induced responses
por: Wu, Jing, et al.
Publicado: (2021)

MRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers
por: Seo, Yoojeong, et al.
Publicado: (2022)

Importance of glycolysis and oxidative phosphorylation in advanced melanoma
por: Ho, Jonhan, et al.
Publicado: (2012)

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
por: Zheng, Xinde, et al.
Publicado: (2016)

Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling Pathway
por: Kim, Gyeongmi, et al.
Publicado: (2022)

Potent Anticancer Effect of the Natural Steroidal Saponin Gracillin Is Produced by Inhibiting Glycolysis and Oxidative Phosphorylation-Mediated Bioenergetics
por: Min, Hye-Young, et al.
Publicado: (2020)

ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth
por: Park, Jongmin, et al.
Publicado: (2022)

Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis
por: Henderson, John, et al.
Publicado: (2020)

A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How?
por: Hewitson, Timothy D., et al.
Publicado: (2021)

CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation
por: Cho, Bongki, et al.
Publicado: (2014)

Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
por: Bae, Kwi-Hyun, et al.
Publicado: (2018)

Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma
por: Byun, Jun-Kyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fr37vmmmudsvso3ggd4f2rfe9v