Cargando…

Evaluation of Substituted N-Phenylpiperazine Analogs as D3 vs. D2 Dopamine Receptor Subtype Selective Ligands

N-phenylpiperazine analogs can bind selectively to the D3 versus the D2 dopamine receptor subtype despite the fact that these two D2-like dopamine receptor subtypes exhibit substantial amino acid sequence homology. The binding for a number of these receptor subtype selective compounds was found to b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Boeun, Taylor, Michelle, Griffin, Suzy A., McInnis, Tamara, Sumien, Nathalie, Mach, Robert H., Luedtke, Robert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198181/ https://www.ncbi.nlm.nih.gov/pubmed/34073405 http://dx.doi.org/10.3390/molecules26113182

Ejemplares similares

Interaction of Ligands for PET with the Dopamine D3 Receptor: In Silico and In Vitro Methods
por: Hsieh, Chia-Ju, et al.
Publicado: (2021)

Antimicrobial activity of meta-alkoxyphenylcarbamates containing substituted N-phenylpiperazine fragment
por: Malík, Ivan, et al.
Publicado: (2012)

Ligand with Two Modes of Interaction with the Dopamine D(2) Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism
por: Ågren, Richard, et al.
Publicado: (2020)

Antimicrobial effect of para-alkoxyphenylcarbamic acid esters containing substituted N-phenylpiperazine moiety
por: Malík, Ivan, et al.
Publicado: (2013)

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.
por: Babich, J. W., et al.
Publicado: (1996)

Synthesis and acaricidal activity of phenylpiperazine derivatives
por: Suzuki, Jun, et al.
Publicado: (2021)

Haloperidol bound D(2) dopamine receptor structure inspired the discovery of subtype selective ligands
por: Fan, Luyu, et al.
Publicado: (2020)

Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870
por: Zhou, Ye, et al.
Publicado: (2019)

Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D(3)-Selective Antagonists
por: Kim, Ho Young, et al.
Publicado: (2022)

Distance Effects of Phenylpiperazine-Containing Methacrylic Polymers on Optical and Structural Properties
por: Derkowska-Zielinska, Beata, et al.
Publicado: (2021)

Fluorescent ligands for dopamine D(2)/D(3) receptors
por: Allikalt, Anni, et al.
Publicado: (2020)

4-Phenylpiperazin-1-ium dihydrogen phosphate
por: Essid, Manel, et al.
Publicado: (2010)

Dopamine D(1), D(2), D(3) Receptors, Vesicular Monoamine Transporter Type-2 (VMAT2) and Dopamine Transporter (DAT) Densities in Aged Human Brain
por: Sun, Jianjun, et al.
Publicado: (2012)

Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing
por: Estrada-Sánchez, Ana María, et al.
Publicado: (2023)

Dopamine agonists in Parkinson’s disease: Impact of D1-like or D2-like dopamine receptor subtype selectivity and avenues for future treatment
por: Isaacson, Stuart H., et al.
Publicado: (2023)

Crystal-structure studies of 4-phenylpiperazin-1-ium 4-ethoxybenzoate monohydrate, 4-phenylpiperazin-1-ium 4-methoxybenzoate monohydrate, 4-phenylpiperazin-1-ium 4-methylbenzoate monohydrate and 4-phenylpiperazin-1-ium trifluoroacetate 0.12-hydrate
por: Mahesha, Ninganayaka, et al.
Publicado: (2022)

Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity
por: Ananthan, Subramaniam, et al.
Publicado: (2014)

1-Phenylpiperazine-1,4-diium bis(hydrogen sulfate)
por: Marouani, Houda, et al.
Publicado: (2010)

1-Chloro-2-(4-phenylpiperazin-1-yl)ethanone
por: Xu, Yong-Ji, et al.
Publicado: (2009)

Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors
por: Sun, Juan, et al.
Publicado: (2015)

Ligand recognition and biased agonism of the D1 dopamine receptor
por: Teng, Xiao, et al.
Publicado: (2022)

The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task
por: Di Ciano, Patricia, et al.
Publicado: (2015)

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
por: Martel, Jean Claude, et al.
Publicado: (2020)

1-Phenylpiperazine-1,4-diium tetrachloridocobalt(II)
por: Dhieb, Abdelhamid Chiheb, et al.
Publicado: (2014)

Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor
por: Liao, Zong-Quan, et al.
Publicado: (2014)

Visualization of ligand-induced dopamine D(2S) and D(2L) receptor internalization by TIRF microscopy
por: Tabor, Alina, et al.
Publicado: (2017)

Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D(3) Receptor Antagonists
por: Chen, Jianyong, et al.
Publicado: (2014)

Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity
por: Peterson, Sean M., et al.
Publicado: (2015)

Dopamine D2-Subtype Receptors Outside the Blood-Brain Barrier Mediate Enhancement of Mesolimbic Dopamine Release and Conditioned Place Preference by Intravenous Dopamine
por: Obray, J. Daniel, et al.
Publicado: (2022)

The Structural Determinants for α(1)-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives
por: Kucwaj-Brysz, Katarzyna, et al.
Publicado: (2021)

Imaging dopamine neurotransmission in Parkinson's disease: biomarker versus surrogate end point
por: Innis, Robert B.
Publicado: (2004)

Synthesis, Molecular Properties Estimations, and Dual Dopamine D(2) and D(3) Receptor Activities of Benzothiazole-Based Ligands
por: Schübler, Moritz, et al.
Publicado: (2017)

Synthesis and anticonvulsant activity of new N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives
por: Kamiński, Krzysztof, et al.
Publicado: (2015)

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition
por: Zhao, Shuo, et al.
Publicado: (2018)

In silico screening of dicarboxylic acids for cocrystallization with phenylpiperazine derivatives based on both cocrystallization propensity and solubility advantage
por: Cysewski, Piotr
Publicado: (2017)

Radiation mitigation of the intestinal acute radiation injury in mice by 1‐[(4‐nitrophenyl)sulfonyl]‐4‐phenylpiperazine
por: Duhachek‐Muggy, Sara, et al.
Publicado: (2019)

Crystal structures of 4-phenylpiperazin-1-ium 6-chloro-5-ethyl-2,4-dioxopyrimidin-1-ide and 4-phenylpiperazin-1-ium 6-chloro-5-isopropyl-2,4-dioxopyrimidin-1-ide
por: Al-Alshaikh, Monirah A., et al.
Publicado: (2015)

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
por: Latawiec, Diane, et al.
Publicado: (2010)

HTML5 Game Programming with enchant.js
por: McInnis, Brandon
Publicado: (2013)

Ligand Discovery from a Dopamine D(3) Receptor Homology Model and Crystal Structure
por: Carlsson, Jens, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_kjfgm6es6qeiihoj68bbhte3dv